Open AccessInhibition on the production of collagen type I, III of activated hepatic stellate cells by antisense TIMP-1 recombinant plasmid
Author(s) -
Wenbin Liu,
Changqing Yang,
Wei Jiang,
Yiqing Wang,
Jing-Sheng Guo,
Bo-Ming He,
Jiyao Wang
Publication year - 2003
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v9.i2.316
Subject(s) - microbiology and biotechnology , western blot , recombinant dna , collagenase , hepatic stellate cell , biology , plasmid , northern blot , interstitial collagenase , transfection , blot , gene expression , gene , biochemistry , enzyme , endocrinology
To investigate the inhibition effects on the production of collagen type I, III secreted by activated rat hepatic stellate cells (rHSCs) by antisense tissue inhibitors of metalloproteinase 1 (TIMP-1) recombinant plasmid through elevating interstitial collagenase activity.