Research ofHelicobacter pyloriinfection in precancerous gastric lesions | Zendy

Xiao Qiang Zhuang | Zendy

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Research ofHelicobacter pyloriinfection in precancerous gastric lesions

Author(s) -

Xiao Qiang Zhuang

Publication year - 2000

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v6.i3.428

Subject(s) - intestinal metaplasia , helicobacter pylori , dysplasia , atrophic gastritis , medicine , cancer , gastroenterology , chronic gastritis , gastritis , helicobacter , precancerous condition , stomach , pathogenesis , metaplasia , pathology

Helicobacter pylori (Hp) infection has been considered to play significant roles in pathogenesis of peptic ulcer. Additionally Hp is associated with the development of gastric epithelial hyperplasia and lymphoid malignancies. The International Agency for Research on Cancer has classified Hp as a class I carcinogen and a definite cause of gastric cancer in humans. Hp infection first causes chronic active gastritis and may slowly lead to infection of whole stomach. In the late stages of infection, mucosal atrophy and intestinal metaplasia (IM), and even dysplasia (DYS) occur[1]. Chronic atrophic gastritis (CAG), IM and DYS are considered markers for development of gastric cancer in high-risk individuals. In our study we analyzed Hp infection prevalence in 486 patients with precancerous gastric lesions.

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