Open AccessEndothelial nitric oxide synthase regulation is altered in pancreas from cirrhotic rats
Author(s) -
JeanLouis Frossard,
Rafael Quadri,
Antoine Hadengue,
Philippe Morel,
Catherine M. Pastor
Publication year - 2006
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v12.i2.228
Subject(s) - enos , medicine , nitric oxide synthase type iii , endocrinology , nitric oxide synthase , cirrhosis , nitric oxide , hsp90 , calmodulin , endothelial nos , biology , heat shock protein , chemistry , biochemistry , calcium , gene
To determine whether biliary cirrhosis could induce pancreatic dysfunction such as modifications in endothelial nitric oxide synthase(eNOS) expression and whether the regulation of eNOS could be altered by the regulatory proteins caveolin and heat shock protein 90 (Hsp90), as well as by the modifications of calmodulin binding to eNOS.
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