Open AccessFrequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-defi cient colorectal cancers
Author(s) -
MariePierre Buisine,
Agnès Wacrenier,
C. Mariette,
Emmanuelle Leteurtre,
Fabienne Escande,
Sana Aissi,
Amandine Ketele,
Annette Leclercq,
Nicole Porchet,
Thécla Lesuffleur
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.1053
Subject(s) - microsatellite instability , colorectal cancer , biology , dna mismatch repair , cancer research , intron , epidermal growth factor receptor , genotype , gene , immunohistochemistry , microsatellite , gene expression , receptor , cancer , genetics , allele , immunology
To investigate the polymorphic simple sequence repeat in intron 1 of the epidermal growth factor receptor gene (EGFR) (CA-SSR I), which is known to affect the efficiency of gene transcription as a putative target of the mismatch repair (MMR) machinery in colorectal tumors.