Effect of Non-Alcoholic Liver Disease on Recurrence Rate and Liver Regeneration after Liver Resection for Colorectal Liver Metastases | Zendy

Nouran Molla | Zendy; Mazen Hassanain | Zendy; Zahir T. Fadel | Zendy; Louis-Martin Boucher | Zendy; A. Madkhali | Zendy; Rahaf Altahan | Zendy; E. A. Alrijraji | Zendy; Ève Simoneau | Zendy; Hussam Alamri | Zendy; Ayat Salman | Zendy; ZuHua Gao | Zendy; Peter P. Metrakos | Zendy

Open Access

Effect of Non-Alcoholic Liver Disease on Recurrence Rate and Liver Regeneration after Liver Resection for Colorectal Liver Metastases

Author(s) -

Nouran Molla,

Mazen Hassanain,

Zahir T. Fadel,

Louis-Martin Boucher,

A. Madkhali,

Rahaf Altahan,

E. A. Alrijraji,

Ève Simoneau,

Hussam Alamri,

Ayat Salman,

ZuHua Gao,

Peter P. Metrakos

Publication year - 2017

Publication title -

current oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.053

H-Index - 51

eISSN - 1718-7729

pISSN - 1198-0052

DOI - 10.3747/co.24.3133

Subject(s) - medicine , steatosis , gastroenterology , fatty liver , colorectal cancer , liver regeneration , hepatectomy , univariate analysis , metastasis , cancer , disease , pathology , multivariate analysis , surgery , regeneration (biology) , resection , biology , microbiology and biotechnology

Resection of metastases is the only potential cure for patients with liver metastasis from colorectal cancer (crc-lm). But despite an improved overall 5-year survival, the recurrence rate is still as high as 60%. Non-alcoholic fatty liver disease (nafld) can decrease the liver's capacity to regenerate after resection and might also affect cancer recurrence, potentially by elevating transforming growth factor β, levels of specific metalloproteinases, and oxidative stress. The objective of the present work was to determine the effect of the histologic features of nafld on cancer recurrence and liver regeneration.

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