MicroRNA Expression Profiling of Sputum for the Detection of Early and Locally Advanced Non-Small-Cell Lung Cancer: A Prospective Case–Control Study | Zendy

Rene Razzak | Zendy; Eric L.R. Bédard | Zendy; J.O. Kim | Zendy; Sayf Gazala | Zendy; Linghong Guo | Zendy; Sunita Ghosh | Zendy; Anil A. Joy | Zendy; Tirath Nijjar | Zendy; Eric Wong | Zendy; Wilson Roa | Zendy

Open Access

MicroRNA Expression Profiling of Sputum for the Detection of Early and Locally Advanced Non-Small-Cell Lung Cancer: A Prospective Case–Control Study

Author(s) -

Rene Razzak,

Eric L.R. Bédard,

J.O. Kim,

Sayf Gazala,

Linghong Guo,

Sunita Ghosh,

Anil A. Joy,

Tirath Nijjar,

Eric Wong,

Wilson Roa

Publication year - 2016

Publication title -

current oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.053

H-Index - 51

eISSN - 1718-7729

pISSN - 1198-0052

DOI - 10.3747/co.23.2830

Subject(s) - sputum , lung cancer , medicine , microrna , oncology , stage (stratigraphy) , non small cell lung cancer (nsclc) , adenocarcinoma , confidence interval , cancer , pathology , biology , gene , a549 cell , tuberculosis , paleontology , biochemistry

Non-small-cell lung cancer (nsclc) is associated with very poor overall survival because 70% of patients present with locally advanced or metastatic disease at the time of diagnosis. Micrornas (mirnas) are a class of short, noncoding rna molecules whose presence in samples of biologic fluids such as sputum has demonstrated promise as a potential means of detecting nsclc. We investigated the stage-specific nsclc detection potential of an efficient panel of 3 mirnas (mir-21, mir-210, mir-372) using a single sputum sample.

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