Open AccessMechanism of regulating deacetylase SIRT1 expression and activity
Author(s) -
WenJia Yang,
Donglai Wang,
WeiGuo Zhu
Publication year - 2011
Publication title -
hereditas (beijing)
Language(s) - English
Resource type - Journals
ISSN - 0253-9772
DOI - 10.3724/sp.j.1005.2010.01003
Subject(s) - mechanism (biology) , sirtuin 1 , microbiology and biotechnology , carcinogenesis , nad+ kinase , senescence , function (biology) , histone deacetylase , biology , biochemistry , genetics , histone , enzyme , downregulation and upregulation , cancer , gene , philosophy , epistemology
SIRT1 is an NAD+-dependent deacetylase in mammalian cells and plays important roles in senescence, cell death and tumorigenesis. To clarify the regulation of SIRT1 expression and activity is crucial for scientists to understand the biological function of SIRT1. This review mainly focuses on the mechanisms by which SIRT1 expression and activity are regulated.
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