Isopulegol apresenta atividade antinociceptiva e outras ações farmacológicas importantes: Uma Revisão Integrativa

Essential oils often have pharmacological effects and therapeutic results. They are complex mixtures of substances (mainly monoterpenes) extracted from aromatic plants. Among these effects, we can highlight antifungal, anti-inflammatory, antioxidant, analgesic activity, among others. Isopulegol (ISO) is a monoterpene alcohol, present in essential plant oils, such as Corymbia citriodora H .; Zanthoxylum schinifolium L. and Melissa officinalis L., these are used in folk medicine as antispasmodic, surgical dressing for wounds, and sedative / hypnotic, memory enhancement and stress-induced headache Brazilian Journal of health Review Braz. J. Hea. Rev., Curitiba, v. 2, n. 5, p. 4271-4280 sep./out. 2019. ISSN 2595-6825 4273 relief. The present work aims to describe the pharmacological actions of the monoterpene ISO presented in the literature. In this way, the electronic database Science Direct, SciELO and PubMed, in the Portuguese, Spanish and English languages, was used as source of search, based on articles published between 2000 and 2017. The keywords used in the research were: Isopulegol. Monoterpene. Pharmacological Activity. Studies have shown that the essential oil of Z. schinifolium L., which contains ISO as a marjoritol compound, is capable of inducing apoptosis of HepG2 human hepatoma cells, besides being able to interrupt the cell cycle of cancer cells in the phases G0 / G1. Research also showed that the ISO presented antioxidant, anxiolytic, antinociceptive, antihyperalgesic, anticonvulsive and sedative activity in rodents, antifungal, gastroprotective and antioxidant properties. ISO also improves pharmacokinetic characteristics of other substances, as well as several pharmacological properties with good perspectives of clinical applicability because it is a substance with a low risk of toxicity and already used by humans for other purposes.