SÍNTESE, ELUCIDAÇÃO DA ARQUITETURA MOLECULAR E AVALIAÇÃO DO POTENCIAL CITOTÓXICO DE UM PROMISSOR CANDIDATO A FÁRMACO DERIVADO DE AMIDOXIMA / SYNTHESIS, ELUCIDATION OF MOLECULAR ARCHITECTURE AND EVALUATION OF THE CYTOTOXIC POTENTIAL OF A PROMISING DRUG CANDIDATE DERIVED FROM AMIDOXIME

Starch is a very important class of compounds, since its applicability is diverse in the most varied fields of knowledge. Specifically, benzamidoxima has important biological activities, such as: hypotensive, trypanosomicidal and tuberculostatic. In view of the various activities of the amidoxime class, this study aimed to synthesize a drug candidate derived from this promising class of biomolecules, 4-methylbenzamidoxima, and to evaluate its toxicity against Artemia salina. 4Methylbenzamidoxime was synthesized from the reaction between benzonitrile and hydroxylamine hydrochloride in a hydroethanolic medium, later characterized by IR and 1H and 13C NMR spectroscopic techniques, while the LC50 of the brine shrimp was determined using the POLO-PC software. As a result, 4-methylbenzamidoxima was obtained in good yield, in the form of a crystalline solid, characterized and the LC50 found through the POLO-PC software, with 95% confidence, was 18.553 μg / mL, which is a high toxicity. Thus, it is extremely important to know not only the biological properties of synthetic products, but also their respective toxic potentials so that they can be applied safely. In view of the above, the positive cytotoxic activity found may function as a pre-assessment for substances with pharmacological potential and be used in studies of structural modification to be possible candidates for drugs.