Open AccessKidney–Gut Crosstalk in AKI
Author(s) -
SangKyung Jo
Publication year - 2021
Publication title -
kidney360
Language(s) - English
Resource type - Journals
ISSN - 2641-7650
DOI - 10.34067/kid.0007722020
Subject(s) - immune system , crosstalk , microbiome , gut flora , dysbiosis , immunology , biology , pathogenesis , innate immune system , disease , inflammatory bowel disease , gastrointestinal tract , medicine , bioinformatics , biochemistry , physics , optics
Bidirectional relationship exist between kidney and intestine during AKI. Kidney IRI provoked dysbiosis, immune cell activation and leaky gut while dysbiosis (as a whole) act as an important modifier of AKI severity. Targeting the intestine/microbiota might provide a new avenue for the prevention and treatment of AKI.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom