Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study | Zendy

Nathan H. Raines | Zendy; Sarju Ganatra | Zendy; Pitchaphon Nissaisorakarn | Zendy; Amar Pandit | Zendy; Alex Morales | Zendy; Aarti Asnani | Zendy; Mehrnaz Sadrolashrafi | Zendy; Rahul Maheshwari | Zendy; Rushin Patel | Zendy; Vigyan Bang | Zendy; Katherine Shreyder | Zendy; Simarjeet Brar | Zendy; Amitoj Singh | Zendy; Sourbha S. Dani | Zendy; Sarah Knapp | Zendy; Ali Poyan Mehr | Zendy; Robert S. Brown | Zendy; Mark L. Zeidel | Zendy; Rhea Bhargava | Zendy; Johannes Schlöndorff | Zendy; Theodore I. Steinman | Zendy; Kenneth J. Mukamal | Zendy; Samir M. Parikh | Zendy

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Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study

Author(s) -

Nathan H. Raines,

Sarju Ganatra,

Pitchaphon Nissaisorakarn,

Amar Pandit,

Alex Morales,

Aarti Asnani,

Mehrnaz Sadrolashrafi,

Rahul Maheshwari,

Rushin Patel,

Vigyan Bang,

Katherine Shreyder,

Simarjeet Brar,

Amitoj Singh,

Sourbha S. Dani,

Sarah Knapp,

Ali Poyan Mehr,

Robert S. Brown,

Mark L. Zeidel,

Rhea Bhargava,

Johannes Schlöndorff,

Theodore I. Steinman,

Kenneth J. Mukamal,

Samir M. Parikh

Publication year - 2020

Publication title -

kidney360

Language(s) - English

Resource type - Journals

ISSN - 2641-7650

DOI - 10.34067/kid.0006452020

Subject(s) - medicine , niacinamide , hazard ratio , acute kidney injury , kidney disease , dialysis , renal replacement therapy , proportional hazards model , prospective cohort study , surgery , nicotinamide , confidence interval , biochemistry , chemistry , enzyme

Background: Acute kidney injury (AKI) is a significant complication of Coronavirus Disease 2019 (COVID-19), with no effective therapy. Niacinamide, a vitamin B3 analog, has some evidence of efficacy in non-COVID-19-related AKI. The objective of this study is to evaluate the association between niacinamide therapy and outcomes in patients with COVID-19-related AKI. Methods: We implemented a quasi-experimental design with non-random, prospective allocation of niacinamide in 201 hospitalized adult patients, excluding those with baseline estimated glomerular filtration rate

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