Open AccessUrinary Citrate Is Associated with Kidney Outcomes in Early Polycystic Kidney Disease
Author(s) -
Daniel Ribeiro da Rocha,
Laixi Xue,
Hiago Murilo Gomes Sousa,
Ana Cristina Carvalho de Matos,
Ewout J. Hoorn,
Mahdi Salih,
Ita Pfeferman Heilberg
Publication year - 2022
Publication title -
kidney360
Language(s) - English
Resource type - Journals
ISSN - 2641-7650
DOI - 10.34067/kid.0004772022
Subject(s) - polycystic kidney disease , autosomal dominant polycystic kidney disease , urinary system , kidney , kidney disease , medicine , urology , endocrinology
Low urinary citrate and crystal deposition accelerated cystogenesis in an experimental model of polycystic kidney disease (PKD).Hypocitraturia, frequently observed in patients with autosomal dominant PKD (ADPKD) could contribute to disease progression.Present findings suggest lower urinary citrate in early PKD was associated with faster eGFR decline and worse kidney survival.