Open AccessMetabolomic Profiling Identifies New Endogenous Markers of Tubular Secretory Clearance
Author(s) -
Michael L. Granda,
David K. Prince,
Oliver Fiehn,
Yan Chen,
Tanya Rajabi,
Catherine K. Yeung,
Andrew N. Hoofnagle,
Bryan Kestenbaum
Publication year - 2022
Publication title -
kidney360
Language(s) - English
Resource type - Journals
ISSN - 2641-7650
DOI - 10.34067/kid.0004172022
Subject(s) - furosemide , renal function , endogeny , chemistry , pharmacokinetics , metabolomics , kidney , secretion , urine , pharmacology , medicine , endocrinology , biology , chromatography , biochemistry
The proximal tubules eliminate protein-bound toxins and drugs through secretion. Measurements or estimates of GFR do not necessarily reflect the physiologically distinct process of secretion. Clinical assessment of this important intrinsic kidney function requires endogenous markers that are highly specific for secretory transport.