Open AccessEndothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice
Author(s) -
Xiaoyi Zheng,
Lauren E. Higdon,
Alexandre Gaudet,
Manav Shah,
Angela Balistrieri,
Catherine Li,
Patricia de Nadaï,
Latha Palaniappan,
XiaoPing Yang,
Briana A. Santo,
Brandon Ginley,
Xiaoxin X. Wang,
Komuraiah Myakala,
Pratima Nallagatla,
Moshe Levi,
Pinaki Sarder,
Avi Z. Rosenberg,
Jonathan S. Maltzman,
Nathalie De Freitas Caires,
Vivek Bhalla
Publication year - 2022
Publication title -
kidney360
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2641-7650
DOI - 10.34067/kid.0001712022
Subject(s) - albuminuria , medicine , podocyte , inflammation , diabetes mellitus , disease , type 2 diabetes , infiltration (hvac) , glomerulosclerosis , endocrinology , cancer research , immunology , kidney , proteinuria , physics , thermodynamics
Diabetic kidney disease (DKD) is the most common cause of kidney failure in the world, and novel predictive biomarkers and molecular mechanisms of disease are needed. Endothelial cell-specific molecule-1 (Esm-1) is a secreted proteoglycan that attenuates inflammation. We previously identified that a glomerular deficiency of Esm-1 associates with more pronounced albuminuria and glomerular inflammation in DKD-susceptible relative to DKD-resistant mice, but its contribution to DKD remains unexplored.