Open AccessImpaired Tubular Secretion of Organic Solutes in Acute Kidney Injury
Author(s) -
Frank O’Brien,
Robert D. Mair,
Natalie S. Plummer,
Timothy W. Meyer,
Scott M. Sutherland,
Tammy L. Sirich
Publication year - 2020
Publication title -
kidney360
Language(s) - English
Resource type - Journals
ISSN - 2641-7650
DOI - 10.34067/kid.0001632020
Subject(s) - renal function , clearance , chemistry , creatinine , secretion , medicine , endocrinology , acute kidney injury , kidney , renal physiology , excretion , fractional excretion of sodium , plasma clearance , urology , pharmacokinetics
Impairment of kidney function is routinely assessed by measuring the accumulation of creatinine, an organic solute cleared largely by glomerular filtration. We tested whether the clearance of solutes that undergo tubular secretion is reduced in proportion to the clearance of creatinine in humans with AKI.
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