Meta-Analysis Of Brain And Central Nervous System Microarray Datasets | Zendy

Icxa Khandelwal | Zendy; Aditi Sharma | Zendy; Jayashree Ramana | Zendy

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Meta-Analysis Of Brain And Central Nervous System Microarray Datasets

Author(s) -

Icxa Khandelwal,

Aditi Sharma,

Jayashree Ramana

Publication year - 2018

Publication title -

international journal for computational biology

Language(s) - English

Resource type - Journals

ISSN - 2278-8115

DOI - 10.34040/ijcb.7.1.2018.97

Subject(s) - central nervous system , microarray analysis techniques , computational biology , neuroscience , microarray , computer science , biology , gene , genetics , gene expression

Brain and CNS cancer are rare in comparison to other types of cancer. Currently there are no effective therapies for their treatment. In this study, meta-analysis of microarray datasets of Brain and CNS cancer was done to obtain significantly upregulated genes with increased statistical power and generalizability. A total of 130 significantly up-regulated genes were obtained. Some of the genes found during analysis have not yet been associated with this cancer. Different biological networks were created and analyzed using the significantly up-regulated genes as input. For each network, the most significant pathways have also been identified computationally.

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