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Background  Even though  Curcuma longa  L. possesses various biological activities, it has strong flavor and taste, which decrease consumer palatability and limit industrial applications in food.    Objective  The present study investigates the effects of  C. longa  L. fermented with  Aspergillus oryzae  supplementation in 60% high-fat diet-induced obese rats measured by the activation of adipogenesis and lipolysis.    Design  Rats were divided into four groups ( n= 6 per group) after 1 week of acclimatization: a normal diet group comprised rats fed the AIN76A rodent diet; a high-fat diet-induced obese group with rats fed a 60% high-fat diet; a  Garcinia cambogia  treated group (positive control) with rats fed a 60% high-fat diet with  G. cambogia  500 g/kg body weight (b.w.)/day; and an fermented  C. longa  L. 50% ethanolic extract treated group (FCE50) with rats fed a 60% high-fat diet with FCE50 500 g/kg b.w./day. Each group received the appropriate vehicle or sample daily by gastric intubation for 12 weeks.    Results  We found that FCE50 administration suppressed b.w. gain and reduced white adipose tissue weight, serum triglyceride (TG), and cholesterol in high-fat diet-induced obese rats. These results can be associated with the suppression of adipocyte differentiation and lipogenesis with a decrease in the mRNA expressions of fatty acid synthase, acetyl-CoA carboxylase, adipocyte protein 2, and lipoprotein lipase induced by FCE50 administration. In addition, FCE50 increased lipolysis and β-oxidation by up-regulating the expression of lipases such as adipose triglyceride lipase, hormone-sensitive lipase, adiponectin, and AMP-activated protein kinase.    Conclusions  These results suggest that FCE50 can be a candidate for the prevention of obesity  via  suppressing adipogenesis and promoting lipolysis.

food and nutrition research/food and nutrition research. supplement

Anti-obesity effect of extract from fermented<i>Curcuma longa</i>L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

Anti-obesity effect of extract from fermentedCurcuma longaL. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats