Development and validation of new analytical method for the estimation of fluoxetine in bulk and dosage form by UV spectrophotometry | Zendy

Uday sankar raju K | Zendy; T. Vimalakkannan | Zendy; K. Ravindra Reddy | Zendy; P. Naveena | Zendy; Rohit Raj | Zendy; S. Subbarayudu | Zendy; T. Hima bindu | Zendy

Open Access

Development and validation of new analytical method for the estimation of fluoxetine in bulk and dosage form by UV spectrophotometry

Author(s) -

Uday sankar raju K,

T. Vimalakkannan,

K. Ravindra Reddy,

P. Naveena,

Rohit Raj,

S. Subbarayudu,

T. Hima bindu

Publication year - 2019

Publication title -

international journal of research in pharmaceutical chemistry and analysis

Language(s) - English

Resource type - Journals

ISSN - 2582-1970

DOI - 10.33974/ijrpca.v1i2.54

Subject(s) - absorbance , fluoxetine , spectrophotometry , relative standard deviation , chromatography , dosage form , chemistry , beer–lambert law , linearity , quantitative analysis (chemistry) , analytical chemistry (journal) , optics , detection limit , physics , biochemistry , receptor , serotonin , quantum mechanics

A simple, rapid and precise method is developed for the quantitative determination of Fluoxetine in combined pharmaceutical-dosage forms. The method was based on UV Spectrophotometric determination of Fluoxetine drug using Beer-Lamberts Law. It involves absorbance measurement at 224 nm (λmax of Fluoxetine) in water. For UV Spectrophotometric method, linearity was obtained in concentration range of 5-30 mcg/ml with regression 0.999 for Fluoxetine respectively. Recovery was in the range of 98 -102%; the value of standard deviation and %R.S.D was found to be < 2 shows high precision of the method.

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