Open AccessSynthesis and Antimicrobial Activities of Gold(I) N-heterocyclic Carbene Complexes
Author(s) -
Gustavo F. Silbestri,
Gabriela A. Fernández,
María Vela Gurovic,
Nelda L. Olivera,
Alicia B. Chopa
Publication year - 2012
Publication title -
proceedings of the 16th international electronic conference on synthetic organic chemistry
Language(s) - English
Resource type - Conference proceedings
DOI - 10.3390/ecsoc-16-01015
Subject(s) - carbene , chemistry , antimicrobial , transmetalation , tetrahydrothiophene , solvent , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis
Water-soluble gold(I) complexes [1-mesityl-3-(3-sodiumsulfonatopropyl)imidazol-2-ylidene] gold(I) Chloro (3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene] gold(I) Chloro (4) were prepared, in high yield, by carbene transmetallation from the appropriate NHC silver complex with chloro tetrahydrothiophene gold ([AuCl(tht)]). The antimicrobial properties of both gold(I) compounds and the respective ligands were assessed by agar diffusion assay and the broth macrodilution method against both Gram-positive and negative bacteria. MICs values (> 128 ug/ml) were superior to those displayed by the reference antibiotics penicillin G and streptomycin.
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