Raman Spectroscopy as a Process Analytical Tool for In-line and Real-time Monitoring of a Pharmaceutical Hot-melt Extrusion Process | Zendy

Lien Saerens | Zendy; Thomas De Beer | Zendy; Jean Paul Remon | Zendy; Chris Vervaet | Zendy

Open Access

Raman Spectroscopy as a Process Analytical Tool for In-line and Real-time Monitoring of a Pharmaceutical Hot-melt Extrusion Process

Author(s) -

Lien Saerens,

Thomas De Beer,

Jean Paul Remon,

Chris Vervaet

Publication year - 2011

Language(s) - English

Resource type - Conference proceedings

DOI - 10.3390/ecps2011-00510

Subject(s) - raman spectroscopy , extrusion , process analytical technology , dispersion (optics) , materials science , analytical chemistry (journal) , amorphous solid , polymer , spectroscopy , calibration , chemistry , chromatography , chemical engineering , composite material , crystallography , optics , physics , statistics , mathematics , quantum mechanics , bioprocess , engineering

The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analy5cal Technology-‐tool (PAT-‐tool) for the in-‐line determina5on of the API content and the polymer-‐drug RAMAN SPECTROSCOPY AS A PROCESS ANALYTICAL TOOL FOR THE IN-LINE AND REAL-TIME MONITORING OF A PHARMACEUTICAL HOTMELT EXTRUSION PROCESS L. SAERENS1, J.P. REMON2, C. VERVAET2, T. DE BEER1 1Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Belgium 2Laboratory of Pharmaceutical Technology, Ghent University, Belgium

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