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The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analy5cal Technology-­‐tool (PAT-­‐tool) for the in-­‐line determina5on of the API content and the polymer-­‐drug RAMAN SPECTROSCOPY AS A PROCESS ANALYTICAL TOOL FOR THE IN-LINE AND REAL-TIME MONITORING OF A PHARMACEUTICAL HOTMELT EXTRUSION PROCESS L. SAERENS1, J.P. REMON2, C. VERVAET2, T. DE BEER1 1Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Belgium 2Laboratory of Pharmaceutical Technology, Ghent University, Belgium

Raman Spectroscopy as a Process Analytical Tool for In-line and Real-time Monitoring of a Pharmaceutical Hot-melt Extrusion Process