Open AccessShaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
Author(s) -
Hong-Tai Tzeng,
ITsu Chyuan,
WeiYu Chen
Publication year - 2019
Publication title -
cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.22
H-Index - 22
ISSN - 2073-4409
DOI - 10.3390/cells8121633
Subject(s) - innate immune system , immune system , acquired immune system , biology , innate lymphoid cell , immunity , inflammation , pattern recognition receptor , microbiology and biotechnology , inflammasome , immunology
Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. Lipid metabolites are emerging as the key players in the regulation of innate immune responses, and recent work has highlighted the importance of the lipid metabolite palmitate as an essential component in this regulation. Palmitate modulates innate immunity not only by regulating the activation of pattern recognition receptors in local innate immune cells, but also via coordinating immunological activity in inflammatory tissues. Moreover, protein palmitoylation controls various cellular physiological processes. Herein, we review the updated evidence that palmitate catabolism contributes to innate immune cell-mediated inflammatory processes that result in immunometabolic disorders.