Development of Spectrophotometric Method for the Determination of Metoclopramide. HCl in a Pharmaceutical Preparations | Zendy

Rowa N. Aljarah | Zendy; Aseel N. Obedagha | Zendy

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Development of Spectrophotometric Method for the Determination of Metoclopramide. HCl in a Pharmaceutical Preparations

Author(s) -

Rowa N. Aljarah,

Aseel N. Obedagha

Publication year - 2014

Publication title -

mağallaẗ ʻulūm al-rāfidayn

Language(s) - English

Resource type - Journals

eISSN - 2664-2786

pISSN - 1608-9391

DOI - 10.33899/rjs.2014.88564

Subject(s) - molar absorptivity , metoclopramide , chemistry , chromatography , pyridoxine , hydrochloric acid , dosage form , spectrophotometry , relative standard deviation , pharmaceutical formulation , absorption (acoustics) , detection limit , materials science , organic chemistry , medicine , surgery , optics , vomiting , biochemistry , physics , composite material

This paper includes a development of spectrophotometric method for the determination of metoclopramide.HCl. The method involves the diazotization of metoclopramide.HCl and coupling with pyridoxine. HCl, to form an intense orange colored, water-soluble and stable azo-dye which shows a maximum absorption at 470 nm. Beer's law is obeyed over the range 0.5-30 μg/ml metaclopramide. HCl with a molar absorptivity of 1.98*10 L.mol.cm, The average recovery is 99.27% and relative standard deviation of ± 0.124 to ± 0.778%. This method has been applied successfully to the determination of metoclopramide.HCl in pharmaceutical preparations.

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