Indirect Determination of Chlorpromazine Hydrochloride by Square Wave Voltammetry of Sodium Nitroprusside: Application to Pharmaceutical Formulations | Zendy

Anfal Raad Mahmood | Zendy

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Indirect Determination of Chlorpromazine Hydrochloride by Square Wave Voltammetry of Sodium Nitroprusside: Application to Pharmaceutical Formulations

Author(s) -

Anfal Raad Mahmood

Publication year - 2013

Publication title -

mağallaẗ ʻulūm al-rāfidayn

Language(s) - English

Resource type - Journals

eISSN - 2664-2786

pISSN - 1608-9391

DOI - 10.33899/rjs.2013.74540

Subject(s) - sodium nitroprusside , square wave , chemistry , hydrochloride , sodium , correlation coefficient , analytical chemistry (journal) , chromatography , mathematics , organic chemistry , voltage , statistics , physics , quantum mechanics , nitric oxide

An indirect voltammetric method was developed for the determination of chlorpromazine hydrochloride (CPZ) via square wave voltammetric behavior of sodium nitroprusside (SNP) which gives a well-defined square wave voltammetric peak at (-0.589)V against the reference electrode (Ag/AgCl/Sat KCl). The addition of CPZ leads to the decrease of the reduction peak of SNP due to the interaction of SNP with CPZ. The decrease in the peak current (∆Ip) was found to be linear and related to the concentration of CPZ within the range of concentration [(0.490×10)-(9.77×10)] M with a correlation coefficient of (0.9948). The method had been successfully applied to determine the CPZ in a pure form and in pharmaceutical formulations.

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