Open AccessSynthesis of some Pyrimidine-2-one and Pyrimidine-2-thione Compounds
Author(s) -
Hiba A. Ebraheem
Publication year - 2013
Publication title -
mağallaẗ ʻulūm al-rāfidayn
Language(s) - English
Resource type - Journals
eISSN - 2664-2786
pISSN - 1608-9391
DOI - 10.33899/rjs.2013.67577
Subject(s) - thiourea , acetophenone , pyrimidinones , benzaldehyde , chemistry , pyrimidine , sodium hydroxide , urea , condensation , semicarbazone , chalcone , organic chemistry , stereochemistry , catalysis , physics , thermodynamics
An efficient synthesis of chalcones (1-7) was achived by condensation of substituted benzaldehyde with substituted acetophenone in ethanolic sodium hydroxide (50%).The chalcones were reacted with urea and thiourea to give the pyrimidinones(8-14) and pyrimidinethiones(15-21) respectively. All the prepared compounds were confirmed by the available physical and spectral methods.
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