Open AccessSynthesis and Antibacterial Evaluation of Some New Fused Cyclic Sulfoxides
Author(s) -
Tahani W. Jihad
Publication year - 2011
Publication title -
mağallaẗ ʻulūm al-rāfidayn
Language(s) - English
Resource type - Journals
eISSN - 2664-2786
pISSN - 1608-9391
DOI - 10.33899/rjs.2011.6796
Subject(s) - steric effects , chemistry , antibacterial activity , condensation , condensation reaction , proton nmr , computational chemistry , combinatorial chemistry , stereochemistry , organic chemistry , bacteria , physics , thermodynamics , genetics , catalysis , biology
A series of diarylidine cyclohexanones (1t-12t) have been prepared via ClasienSchmidt reaction then condensed with dimethyl sulphoxide through Michael-Claisen condensation to afford the corresponding fused heterocycles (13t-24t). The structures of the products were elucidated by the spectrum (UV, IR, 1 H-NMR). The suggested mechanisms for these reactions were investigated according to theoretical calculations, heat of formation (H.F.) and the steric energy (S.E.). Furthermore some of the products have been tested for their biological activity (antibacterial).
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