Pathological Study of Acute Oral Toxicity Induced by Plasticizer Di (2- ethyl hexyl) Phthalate in Japanese Common Quails Coturnix coturnix japanies | Zendy

Saevan S. Al-Mahmood | Zendy; S.M. Al-Abady | Zendy

Open Access

Pathological Study of Acute Oral Toxicity Induced by Plasticizer Di (2- ethyl hexyl) Phthalate in Japanese Common Quails Coturnix coturnix japanies

Author(s) -

Saevan S. Al-Mahmood,

S.M. Al-Abady

Publication year - 2017

Publication title -

al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/iraqi journal of veterinary sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 9

eISSN - 2071-1255

pISSN - 1607-3894

DOI - 10.33899/ijvs.2017.126714

Subject(s) - coagulative necrosis , histopathology , toxicity , necrosis , quail , steatosis , edema , infiltration (hvac) , nephrotoxicity , kidney , no observed adverse effect level , pathology , physiology , medicine , endocrinology , physics , thermodynamics

The current study aimed to identified the pathological changes of oral toxicity induced by Di (2-ethyl hexyl) phthalate (DEHP) in Japanese common quail. To a chief this aim a pilot study conducted to determine the median lethal dose (LD50) of DEHP. Forty male quails one day old were divided randomly into two equal groups, the first group was orally administrated by 10% of LD50 of DEHP daily for fourteen days, while second group was considered as control group and left without treatment all over the experimental time. The result of pilot study showed that the LD50 of DEHP in quails is 5574,1 mg/kg of body weight and the dose used in experiment to induced the acute oral toxicity was 557.4 mg/kg of quail's body weight. The result of gross pathological appearance of euthanized quails at fourteen days of experiment revealed presence of sever congestion in kidney lobules as well as congestion of liver with hemorrhagic ecchymotic patches while at other case the liver دلجملا ،ةيرطيبلا مولعلل ةيقارعلا ةلجملا ٣١ ددعلا ، ١ ، ٢٠١٧ ) ١٧ ٢٤ (

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