Long-term toxicological effects of paracetamol in rats | Zendy

Saima Majeed | Zendy; Mukhallad Abdul Kareem Ramadhan | Zendy; W. Monther | Zendy

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Long-term toxicological effects of paracetamol in rats

Author(s) -

Saima Majeed,

Mukhallad Abdul Kareem Ramadhan,

W. Monther

Publication year - 2013

Publication title -

al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/iraqi journal of veterinary sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 9

eISSN - 2071-1255

pISSN - 1607-3894

DOI - 10.33899/ijvs.2013.82959

Subject(s) - antipyretic , medicine , analgesic , drug , acetaminophen , pharmacology , medical prescription , oral administration , kidney , anesthesia

The analgesic and antipy retic properties of paracetamol were first described in 1893, then it has been widely available as a non-prescription drug, with a therapeutic profile that reflects widespread safety and efficacy as well as paracetamol became the most widely used analgesic and antipy retic in children. It is the most frequently used over-the counter medicine in y oung children and is nearly universally used in infants. The drug is used by millions of children every day . The study was designed to study the toxicological effect of therapeutic dose of paracetamol after oral administration for three months in laboratory rats (Rattus norvegicous ) on the heart, kidney and liver. Results showed oral administration of the paracetamol for three months in laboratory rats showed that this drug has a severe damaging effect on most of the vital organs in the body like kidney, liver and heart.

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