Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups | Zendy

H. M. Jassim | Zendy; A. A. Hassan | Zendy

Open Access

Effect of treating lactating rats with lead acetate and its interaction with vitamin E or C on neurobehavior, development and some biochemical parameters in their pups

Author(s) -

H. M. Jassim,

A. A. Hassan

Publication year - 2010

Publication title -

al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/iraqi journal of veterinary sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.391

H-Index - 9

eISSN - 2071-1255

pISSN - 1607-3894

DOI - 10.33899/ijvs.2010.5584

Subject(s) - malondialdehyde , lead acetate , endocrinology , medicine , vitamin e , lactation , vitamin , glutathione , antioxidant , oral administration , chemistry , biology , toxicity , pregnancy , biochemistry , oxidative stress , enzyme , genetics

The current study investigated the effect of administration of vitamin E (600mg / kg diet) concomitantly with lead acetate (10mg /kg, orally) and vitamin C (100mg /kg, orally) concomitantly with lead acetate (10mg /kg, orally) to the female lactating rats on the neurobehavioral, landmarks development and some biochemical tests in their pups. Administration of lead acetate to the female lactating rats caused a significant increase in open field activity test including (the number of squares crossed and rearing test within 3 minutes), olfactory discrimination test, triglycerides and malondialdehyde brain tissue, with a significant decrease in glutathione brain tissue and high density lipoproteins in their pups. The present study demonstrated that treatment of female lactating rats with vitamin C and lead acetate produced a significant decrease in righting reflex test in their pups. Administration of vitamin E concomitantly with lead acetate to the female lactating rats caused a significant increase in glutathione level accompanied with a significant decrease in malondialdehyde and triglycerides levels in their pups. The present study showed that treatment of female lactating rats with vitamin E or C with lead acetate produced a significant decrease in rearing test, whereas a significant increase in high density lipoproteins in their pups. It is concluded that administration vitamin E or C to the female lactating rats reverse the adverse effects produced by lead acetate on neurobehavioral. Vitamin E had positive effect on the levels of glutathione, malondialdehyde brain tissue, triglyceride and high density lipoproteins in their lactating pups.

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