Spectrophotometric Determination of Chloramphenicol in Pharmaceutical Preparations | Zendy

Tamathir Abbas Hamoudi | Zendy; Wadala A. Bashir | Zendy

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Spectrophotometric Determination of Chloramphenicol in Pharmaceutical Preparations

Author(s) -

Tamathir Abbas Hamoudi,

Wadala A. Bashir

Publication year - 2018

Publication title -

mağallaẗ al-tarbiyaẗ wa-al-ʻilm

Language(s) - English

Resource type - Journals

eISSN - 2664-2530

pISSN - 1812-125X

DOI - 10.33899/edusj.2018.159308

Subject(s) - molar absorptivity , chloramphenicol , chemistry , chromatography , reagent , cerium , spectrophotometry , relative standard deviation , absorption (acoustics) , nitro , analytical chemistry (journal) , nuclear chemistry , detection limit , materials science , inorganic chemistry , antibiotics , organic chemistry , optics , physics , alkyl , composite material , biochemistry

A spectrophotometric method for the determination of trace amounts of chloramphenicol has been proposed. This method depends upon the reduction of the nitro to amino group, condensation with promethazine reagent in the presence of cerium (IV) ions to form a colored dye which exhibits maximum absorption at 606 nm with a high sensitivity (molar absorptivity is 1.292×10 4 l.mol -1 .cm -1 , and Sandell's sensitivity index of 0.025 μg/cm 2 ). Beer' s law is applied within the concentration range of obeyed in 0.4 to 12 ppm with a relative error of -2.73 to + 0.37% and a relative standard deviation of ± 3.84 to ± 0.44%, depending on the concentration level. The method has been successfully applied to the

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