Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent | Zendy

Usra Al-Neaimy | Zendy

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Spectrophotometric Estimation of Ganciclovir in Pharmaceutical Formulations using Alizarin Sulfonic Acid Sodium Salt Reagent

Author(s) -

Usra Al-Neaimy

Publication year - 2013

Publication title -

mağallaẗ al-tarbiyaẗ wa-al-ʻilm

Language(s) - English

Resource type - Journals

eISSN - 2664-2530

pISSN - 1812-125X

DOI - 10.33899/edusj.2013.89818

Subject(s) - reagent , chemistry , molar absorptivity , chromatography , dosage form , sulfonic acid , absorbance , salt (chemistry) , alizarin red , alizarin , spectrophotometry , aqueous solution , ganciclovir , sodium , nuclear chemistry , organic chemistry , medicine , staining , biochemistry , physics , pathology , human cytomegalovirus , gene , optics

A simple and rapid spectrophotometric method has been developed for the determination of antiviral drug (Ganciclovir) in a bulk sample and in its dosage forms. The method depends on the ion-pair formation reaction of the drug with alizarin sulfonic acid sodium salt reagent in aqueous solution to form a pinkish red color product showing maximum absorbance at 525 nm. Beers law is obeyed in the concentration range 2 – 100 μg.ml with average recovery (accuracy) 99.80% and precision (RSD) is less than 1.0%. The molar absorptivity is 4.59x10 l.mol.cm with LOD 0.17 μg.ml and LOQ 0.56 μg.ml. The method is successfully employed for the determination of Ganciclovir in pharmaceutical formulations as an injection and capsule and the results Spectrophotometric Estimation of Ganciclovir in Pharmaceutical ... 66 are compatible with both certified values of pharmaceutical formulations and the standard addition method.

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