English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Taste buds develop in different regions of the mammal oral cavity. Adult stem cells in various organs including the tongue papillae are marked by leucine-rich repeat-containing G protein-coupled receptor 5 ( Lgr5 ) and its homolog,  Lgr6 . Recent studies have reported that adult taste stem/progenitor cells in circumvallate papilla (CVP) on the posterior tongue are  Lgr5 -positive. In this study, we confirm the  Lgr5  expression pattern during CVP development. A previous study reported that mesenchymal  Fgf10  is necessary for maintaining epithelial  Lgr5 -positive stem/progenitor cells. To confirm the interaction between  Lgr5 -positive CVP epithelium and mesenchymal factor FGF10, reverse recombination (180-degree) was performed after tongue epithelium detachment. FGF10 protein-soaked bead implantation was performed after reverse recombination to rescue CVP development. Moreover, we reduced mesenchymal  Fgf10  by BIO and SU5402 treatment which disrupted CVP morphogenesis. This study suggests that the crosstalk between epithelial  Lgr5  and mesenchymal  Fgf10  plays a pivotal role in CVP epithelium invagination during mouse tongue CVP development by maintaining  Lgr5 -positive stem/progenitor cells.

FGF10 Is Required for Circumvallate Papilla Morphogenesis by Maintaining Lgr5 Activity