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Although the functions of long noncoding RNA (lncRNA) called FOXD2 adjacent opposite strand RNA 1 ( FOXD2-AS1 ) have been well studied in multiple human cancer types, its expression status and detailed roles in cervical cancer remain unknown and merit investigation. This study was aimed at assessing  FOXD2-AS1  expression in cervical cancer and at determining its effects on the aggressive behavior of cervical cancer  in vitro  and  in vivo . Expression of  FOXD2-AS1  in cervical cancer tissues and cell lines was determined  via  reverse-transcription quantitative PCR. The effects of  FOXD2-AS1  on cervical cancer cells were examined by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, flow-cytometric analysis, migration and invasion assays, and an  in vivo  tumorigenicity assay.  FOXD2-AS1  was found to be significantly upregulated in cervical cancer tissues and cell lines. High  FOXD2-AS1  expression was notably linked with the Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and depth of cervical invasion in patients with cervical cancer. Kaplan–Meier survival analysis revealed significantly shorter overall survival of patients when the tumor expression of  FOXD2-AS1  was higher in comparison with those in patients with lower  FOXD2-AS1  expression.  In vitro  functional assays revealed that downregulation of  FOXD2-AS1  led to suppression of proliferation, migration, and invasiveness as well as to the induction of apoptosis of cervical cancer cells. In addition,  FOXD2-AS1  silencing hindered tumor growth  in vivo . Mechanism investigation revealed that  FOXD2-AS1  functioned as a molecular sponge of microRNA-760 (miR-760). Furthermore, hepatoma-derived growth factor ( HDGF ) was validated as a direct target gene of miR-760 in cervical cancer cells. Moreover, an miR-760 knockdown reversed the effects of  FOXD2-AS1  silencing on cervical cancer cells.  FOXD2-AS1  possesses significant oncogenic activity in cervical cancer progression; this activity is mediated by sponging of miR-760 with consequent upregulation of HDGF. The  FOXD2-AS1 –miR-760–HDGF axis might harbor promising targets for novel treatment strategies of cervical cancer.

Long Noncoding RNA FOXD2-AS1 Promotes the Malignancy of Cervical Cancer by Sponging MicroRNA-760 and Upregulating Hepatoma-Derived Growth Factor