Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient | Zendy

Huan Xia | Zendy; Yuanlin Guan | Zendy; Silvère D. Zaongo | Zendy; Han Xia | Zendy; Ziyu Wang | Zendy; Zhongfang Yan | Zendy; Ping Ma | Zendy

Open Access

Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient

Author(s) -

Huan Xia,

Yuanlin Guan,

Silvère D. Zaongo,

Han Xia,

Ziyu Wang,

Zhongfang Yan,

Ping Ma

Publication year - 2019

Publication title -

frontiers in neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.23

H-Index - 67

ISSN - 1664-2295

DOI - 10.3389/fneur.2019.01202

Subject(s) - metagenomics , progressive multifocal leukoencephalopathy , cerebrospinal fluid , leukoencephalopathy , dna sequencing , medicine , human immunodeficiency virus (hiv) , pathology , virology , virus , biology , genetics , gene , disease

Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy (PML).

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