Neuroimaging of Cerebral Small Vessel Disease and Age-Related Cognitive Changes | Zendy

Michelle R. Caunca | Zendy; Andrés De León-Benedetti | Zendy; Lawrence L. Latour | Zendy; Richard Leigh | Zendy; Clinton B. Wright | Zendy

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Neuroimaging of Cerebral Small Vessel Disease and Age-Related Cognitive Changes

Author(s) -

Michelle R. Caunca,

Andrés De León-Benedetti,

Lawrence L. Latour,

Richard Leigh,

Clinton B. Wright

Publication year - 2019

Publication title -

frontiers in aging neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.827

H-Index - 78

ISSN - 1663-4365

DOI - 10.3389/fnagi.2019.00145

Subject(s) - neuroimaging , subclinical infection , cognition , disease , context (archaeology) , cognitive decline , pathological , medicine , etiology , neuroscience , population , psychology , magnetic resonance imaging , dementia , pathology , radiology , biology , environmental health , paleontology

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of different types of lesions may help investigators differentiate between age-related and pathological cerebrovascular damage in cognitive aging. In this review article, we aim to describe the epidemiology and etiology of various brain magnetic resonance imaging (MRI) measures of vascular damage in cognitively normal, older adult populations. We focus here on population-based prospective cohort studies of cognitively unimpaired older adults, as well as discuss the heterogeneity of MRI findings and their relationships with cognition. This review article emphasizes the need for a better understanding of subclinical cerebrovascular disease in cognitively normal populations, in order to more effectively identify and prevent cognitive decline in our rapidly aging population.

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