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Chemotaxis-mediated motility enables  Campylobacter jejuni  to navigate through complex environmental gradients and colonize diverse niches.  C. jejuni  is known to possess several methyl accepting chemotaxis proteins (MCPs), also called transducer-like proteins (Tlps). While the role of some of the Tlps in chemotaxis has been identified, their regulation and role in virulence is still not very clear. Here, we investigated the contribution of Tlp2 to  C. jejuni  chemotaxis, stress survival and colonization of the chicken gastrointestinal tract. The Δ tlp2  deletion mutant showed decreased chemotaxis toward aspartate, pyruvate, inorganic phosphate (Pi), and iron (FeSO 4 ). Transcriptional analysis of  tlp2  with a promoter fusion reporter assay revealed that the  tlp2  promoter (P  tlp2  ) was induced by Pi and iron, both in the ferrous (Fe 2+ ) and ferric form (Fe 3+ ). RT-PCR analysis using overlapping primers indicated that the  phoX  gene, located immediately downstream of  tlp2,  is co-transcribed with  tlp2 . A transcription start site was identified at 53 bp upstream of the  tlp2  start codon. The Δ tlp2  mutant showed decreased colonization of the chicken gastrointestinal tract. Collectively, our findings revealed that the  tlp2  plays a role in  C. jejuni  pathogenesis and colonization in the chicken host and its expression is regulated by iron.

Transducer-Like Protein in Campylobacter jejuni With a Role in Mediating Chemotaxis to Iron and Phosphate