Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids | Zendy

Lisa F. Stinson | Zendy; Melvin Gay | Zendy; Petya Koleva | Zendy; Merete Eggesbø | Zendy; Christine Johnson | Zendy; Ganesa Wegienka | Zendy; Elloise du Toit | Zendy; Naoki Shimojo | Zendy; Daniel Munblit | Zendy; Dianne E. Campbell | Zendy; Susan L. Prescott | Zendy; Donna T. Geddes | Zendy; Anita L. Kozyrskyj | Zendy

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Human Milk From Atopic Mothers Has Lower Levels of Short Chain Fatty Acids

Author(s) -

Lisa F. Stinson,

Melvin Gay,

Petya Koleva,

Merete Eggesbø,

Christine Johnson,

Ganesa Wegienka,

Elloise du Toit,

Naoki Shimojo,

Daniel Munblit,

Dianne E. Campbell,

Susan L. Prescott,

Donna T. Geddes,

Anita L. Kozyrskyj

Publication year - 2020

Publication title -

frontiers in immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.646

H-Index - 124

ISSN - 1664-3224

DOI - 10.3389/fimmu.2020.01427

Subject(s) - butyrate , atopy , atopic dermatitis , immune system , obesity , allergy , overweight , breastfeeding , food science , short chain fatty acid , chemistry , fermentation , medicine , biology , endocrinology , immunology , pediatrics

Short chain fatty acids (SFCAs) are microbial metabolites produced in the gut upon fermentation of dietary fiber. These metabolites interact with the host immune system and can elicit epigenetic effects. There is evidence to suggest that SCFAs may play a role in the developmental programming of immune disorders and obesity, though evidence in humans remains sparse. Here we have quantified human milk (HM) SCFA levels in an international cohort of atopic and non-atopic mothers ( n = 109). Our results demonstrate that human milk contains detectable levels of the SCFAs acetate, butyrate, and formate. Samples from atopic mothers had significantly lower concentrations of acetate and butyrate than those of non-atopic mothers. HM SCFA levels in atopic and non-atopic women also varied based on maternal country of residence (Australia, Japan, Norway, South Africa, USA). Reduced exposure to HM SCFA in early life may program atopy or overweight risk in breastfed infants.

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