Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape | Zendy

Asma Ahmed | Zendy; Christian Schmidt | Zendy; Thomas Brunner | Zendy

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Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape

Author(s) -

Asma Ahmed,

Christian Schmidt,

Thomas Brunner

Publication year - 2019

Publication title -

frontiers in immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.646

H-Index - 124

ISSN - 1664-3224

DOI - 10.3389/fimmu.2019.01438

Subject(s) - immune system , homeostasis , glucocorticoid , hormone , intestinal mucosa , intestinal epithelium , biology , inflammation , immunology , epithelium , endocrinology , medicine , pathology

Glucocorticoids (GCs) are steroid hormones predominantly produced in the adrenal glands in response to physiological cues and stress. Adrenal GCs mediate potent anti-inflammatory and immunosuppressive functions. Accumulating evidence in the past two decades has demonstrated other extra-adrenal organs and tissues capable of synthesizing GCs. This review discusses the role and regulation of GC synthesis in the intestinal epithelium in the regulation of normal immune homeostasis, inflammatory diseases of the intestinal mucosa, and the development of intestinal tumors.

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