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Lung adenocarcinoma with  CTNNB1  mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied.    Methods  A total of 564 lung adenocarcinoma patients were enrolled in this study. The relationship between  CTTNB1  mutational status and clinicopathologic parameters, the rates of relapse-free survival (RFS) and overall survival (OS), and the mutational status of other genes commonly mutated in lung adenocarcinoma were analyzed.    Results  Of 564 lung adenocarcinoma patients, 30 (5.3%) harbored  CTNNB1  mutations. Univariate analyses revealed that gender, smoking history, pleural invasion, and histological subtype were all significant predictors of RFS and OS. Pleural invasion and histological subtype remained significant predictors of RFS and OS in a multivariate analysis. There were no significant differences in RFS ( p  = 0.504) or OS ( p  = 0.054) between lung adenocarcinoma patients with  CTNNB1  mutation and those without  CTNNB1  mutation. However, patients with  CTNNB1  mutation tended to have a worse OS.    Conclusions  Female patients and nonsmokers are likely to harbor  CTNNB1  mutation and primary lung adenocarcinoma with mutated  CTNNB1  has a poor prognosis.

Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With CTNNB1 Mutation