Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes | Zendy

Tilman Schultze | Zendy; Benjamin Izar | Zendy; Xiaoxing Qing | Zendy; Gopala Krishna Mannala | Zendy; Torsten Hain | Zendy

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Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes

Author(s) -

Tilman Schultze,

Benjamin Izar,

Xiaoxing Qing,

Gopala Krishna Mannala,

Torsten Hain

Publication year - 2014

Publication title -

frontiers in cellular and infection microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.812

H-Index - 75

ISSN - 2235-2988

DOI - 10.3389/fcimb.2014.00135

Subject(s) - listeria monocytogenes , biology , rna , gene , listeria , virulence , antisense rna , genome , computational biology , context (archaeology) , human pathogen , genetics , bacteria , microbiology and biotechnology , paleontology

Listeria monocytogenes is a Gram-positive human-pathogen bacterium that served as an experimental model for investigating fundamental processes of adaptive immunity and virulence. Recent novel technologies allowed the identification of several hundred non-coding RNAs (ncRNAs) in the Listeria genome and provided insight into an unexpected complex transcriptional machinery. In this review, we discuss ncRNAs that are encoded on the opposite strand of the target gene and are therefore termed antisense RNAs (asRNAs). We highlight mechanistic and functional concepts of asRNAs in L. monocytogenes and put these in context of asRNAs in other bacteria. Understanding asRNAs will further broaden our knowledge of RNA-mediated gene regulation and may provide targets for diagnostic and antimicrobial development.

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