Preparation of MMP-sensitive hyaluronic acid hydrogels and their impact on cell migration | Zendy

Shan Yu | Zendy; Mao Zhengwei | Zendy; Changyou Gao | Zendy

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Preparation of MMP-sensitive hyaluronic acid hydrogels and their impact on cell migration

Author(s) -

Shan Yu,

Mao Zhengwei,

Changyou Gao

Publication year - 2016

Publication title -

frontiers in bioengineering and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.081

H-Index - 44

ISSN - 2296-4185

DOI - 10.3389/conf.fbioe.2016.01.01199

Subject(s) - hyaluronic acid , self healing hydrogels , extracellular matrix , matrix metalloproteinase , cell migration , tissue engineering , chemistry , wound healing , drug delivery , matrix (chemical analysis) , cell , materials science , biophysics , biomedical engineering , nanotechnology , biochemistry , polymer chemistry , anatomy , biology , immunology , medicine , chromatography

Mimicking the structures and functions of extracellular matrix (ECM) is an important guidance for biomaterials design. ECM takes a key role in signal transduction. For example, enzymes are secreted or locally activated by migrating cells to degrade, and then to remodel the ECM. Therefore, a 3D matrix simulating the structure and function of ECM provides a better model system of physiological environment for cell migration study. Hyaluronic acid (HA) derivatives are widely used in biomedical field. The present study mainly focuses on the fabrication of an active and cell-responsive HA-based hydrogel. The migration of vascular smooth muscle cells (SMCs) is studied in the 3D matrix.

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