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Mimicking the structures and functions of extracellular matrix (ECM) is an important guidance for biomaterials design. ECM takes a key role in signal transduction. For example, enzymes are secreted or locally activated by migrating cells to degrade, and then to remodel the ECM. Therefore, a 3D matrix simulating the structure and function of ECM provides a better model system of physiological environment for cell migration study. Hyaluronic acid (HA) derivatives are widely used in biomedical field. The present study mainly focuses on the fabrication of an active and cell-responsive HA-based hydrogel. The migration of vascular smooth muscle cells (SMCs) is studied in the 3D matrix.

Preparation of MMP-sensitive hyaluronic acid hydrogels and their impact on cell migration