Preparation, Characterization and In-Vitro Evaluation of Atorvastatin Calcium Solid Dispersions with Various Hydrophilic Polymers and Its FDT Formulation.

The aim of the present research was to improve the solubility and hence enhance the dissolution of hydrophobic drug Atorvastatin calcium (ATV) in order to increase its bioavailability. Solid dispersion of atorvastatin calcium using various carriers like PEG 4000, PEG 6000, PVP K30, Poloxamer 407 were formulated in different ratios by fusion and solvent evaporation method. The formulations were then evaluated to choose the best carrier which showed enhanced dissolution rate in phosphate buffer (pH 6.8). The best dissolution results were with Poloxamer 407 in the ratio of 1:2. The solid dispersion formulated with Poloxamer 407 carrier was further developed into fast dissolving tablet and evaluated for in vitro dissolution, drug content analysis and disintegration time. Results showed that the FDT made with the formulated solid dispersion (Poloxamer 407 ratio 1:2) showed enhanced dissolution within a quick time.