Polarographic and Pharmacological study of Zn (II)-Paracetamol complex. | Zendy

Rakesh Choure | Zendy; Neelam Vaidya | Zendy

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Polarographic and Pharmacological study of Zn (II)-Paracetamol complex.

Author(s) -

Rakesh Choure,

Neelam Vaidya

Publication year - 2011

Publication title -

journal of current pharma research

Language(s) - English

Resource type - Journals

eISSN - 2230-7842

pISSN - 2230-7834

DOI - 10.33786/jcpr.2011.v01i02.006

Subject(s) - polarography , chemistry , pharmacology , nuclear chemistry , inorganic chemistry , medicine

The formation of complexes of paracetamol and Zn (II) was studied in aqueous media at pH 7.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between paracetamol and Zn (II). Paracetamol produces a well-defined direct current polarogram and differential pulse polarogram in 1M Britton Robinson buffer (supporting electrolyte) at pH 7.2±0.1. The stoichiometry of the Zn (II)-Paracetamol complex is 1:1. Analgesic studies on the drug and its metal complex have been performed in albino mice. Revealing the complex to be more potent in analgesic activity compared to the parent drug.

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