HISTOLOGICAL TOXIC EFFECT OF NANDROLONE DECANOATE ON THE KIDNEY OF MALE RABBITS: Part one

Over the past several decades it has been known that there are an increase in the prevalence of anabolic steroid use by athletes. The pathophysiology and prognosis of anabolic-androgenic steroid use remains unclear. The aim of this study is to investigate the histological toxic effects of nandrolone decanoate on the kidney of male rabbits. 21 rabbits were divided into three groups; each consists of 7 animals. The control group was injected with normal saline. Group (І) received 2mg/kg body weight, and group (П) received 6mg/kg body weight. Animals received the dose weekly for 2 months duration. There was an increase in the weights of kidney of group (П) compared to other groups. The histological pattern of the kidney of group(І) was nearly normal, while kidney of group (П) showed more severe pathological damage which includes enlargement and hypercellularity including the mesangial cells of the renal glomerular tuft with narrowing of Bowman's capsule. Vacuolar degeneration of the lining epithelium of the proximal convoluted tubules and some tubules showed sloughing and necrosis of the epithelial cells. These results showed that nandrolone decanoate had histological toxic effects on the kidney of rabbits.