UNUSUAL PRESENTATION OF A COMMON DISEASE

This study aimed to describe the clinical features of acute rupture of hydatid cyst in the peritoneum. We retrospectively studied 7 patients who underwent explorative laparotomy between January 2002 and October 2005, and in whom exploration confirmed the rupture of hydatid cyst in the peritoneum. Rupture was secondary to trauma in 2 patients, and occurred spontaneously in 5 patients. All patients presented with acute peritonitis, and anaphylactic shock developed in 4 patients. One patient died postoperatively. Ultrasonogrophic diagnosis was made in 3 patients. Surgical treatment consisted of the treatment of peritonitis, the ruptured hydatid cyst and evacuation of the free intraperitoneal hydatid fluid. All patients kept on albendazole. Acute rupture of hydatid cyst in the peritoneum should be considered when evaluating acute abdomen in endemic areas. Introduction ydatid disease (Echinococcosis) is a common disease distributed in most of the world, especially in the sheep rearing areas where it is endemic in many countries including Iraq 1-4 . The disease can be caused by one of three species of the genus Echinococcus(E.granulosus, E.multilocularis& E.voegeli) 5, 6 . Echinococcal cyst is the larval cystic stage of a small taeniid type tape worm (usually E. granulosus) 7, 8 . The adult worm (3-6mm long) inhabits the small intestine of carnivorous definitive hosts such as dogs or wolves, and echinococcal cyst stage occur in herbivorous intermediate hosts such as sheep, cattle and goats 7, 9 . In the typical dog-sheep cycle, tape worm eggs are passed in feces of an infected dog and may subsequently be ingested by sheep, they hatch into embryos in the intestine, penetrate the intestinal lining, and then are picked up and carried by blood throughout the body to major filtering organ (mainly liver and, or lungs). Then they transform and develop into larval echinococcal cysts in which numerous heads (protoscolices) are produced by asexual reproduction 1,2,7,10,11 . Cysts are produced by the peri parasitic host tissues (pericyst) which encompasses the endocyst of larval origin, inside the laminated layer the cyst is covered by a multipotential germinal layer giving rise to bulblike processes which are termed brood capsules which produce numerous protoscolices.6 In addition daughter cysts of variable size are often detected. The clinical features of hydatid disease are highly variable 1,2 . Cystic lesions cause symptoms via compressing adjacent organs or may be H Unusual presentation of a common disease Mazin Abdullah, Noori Jasim, Furat Shani Bas J Surg, September, 12, 2006 totally silent. Sudden symptomatology is usually due to spontaneous or traumatic rupture of the echinococcal cyst with or without anaphylaxis 12,13 . Cysts may rupture into the peritoneal or pleural cavity 12-16 bile ducts, the pericardium or even blood vessels leading to extraordinary manifestations and severe complications. This article discusses those patients who presented as acute abdomen due to rupture of the cyst. Methods We retrospectively studied 7 patients presented with features of acute abdomen, and who had underwent surgery between January 2002 and October 2005 in Basra General Hospital and in whom the exploration had confirmed the diagnosis of acute rapture of echinococcal cyst in the peritoneum. We present the cases shortly. Case 1 A thirty years old man presented with generalized abdominal pain few hours after a road traffic accident. His blood pressure was normal but he had tachycardia, the abdomen was tender all over with rigidity. No sonographic or x-rays service was available, so explorative laparotomy was decided, On exploration, huge amount of bile stained fluid was found in the peritoneal cavity and a ruptured large hydatid cyst found in the right-lobe of liver, which was still containing some daughter cysts, no other pathologies found. After clearing of the cyst, suction of free fluid and irrigation by hypertonic saline, abdomen closed leaving a tube drain. The drainage of bile stained fluid continue for one month of about 500 ml. daily. The patient referred for ERCP in a gastro-entrology center where a filling defect found in the common bile duct (membrane of the cysts).Sphincterotomy performed and the drainge ceased after two weeks. Patient was kept on albendazole. Case 2 A thirty two years old man was admitted to the waiting surgical ward because of sudden, severe upper abdominal pain of 2 hours duration. There was no history of trauma; patient rapidly passed into a shock state, pulse was 130/minute. The abdomen was rigid and mildly distended. Resuscitation started by intravenous ringer solution in addition to hydrocortisone. After improvement sonographic examination (figure-1) discovered a ruptured hydatid cyst in the left lobe of the liver, the cyst found collapsed but no free intraperitoneal fluid could be detected. The cyst dealt with surgically in the routine way. Patient improved gradually and discharged well after 8 days. Case 3 A fifty years old man presented with shock to the medical emergency unit. His pulse rate was 120/ minute and his blood pressure was80/40 mm. Hg, his ECG was normal apart from tachycardia. Chest was clear. Resuscitation started and surgical consultation Sought. The surgeon found tense, tender abdomen, and sonographic examination revealed presence of free intrapeitoneal fluid. Chest x-ray was normal. Emergency explorative laparotomy confirmed presence of a ruptured hydatid cyst in right lobe of liver. Abdomen closed after dealing with the cyst and leaving a drain. Patient discharged well after 10 days and was kept on albendazole. Unusual presentation of a common disease Mazin Abdullah, Noori Jasim, Furat Shani Bas J Surg, September, 12, 2006 Case 4 A 46 years old lady with history of trauma presented with acute abdomen. She got tachycardia while her blood pressure normal .Ultrasound examination found multiple cysts free in the peritoneal cavity while chest x ray & ECG were normal. Explorative laparotomy performed few hours later and revealed a ruptured large hydatid cyst in the right lobe of the liver with spillage of hundreds of daughter cysts of varying sizes all over the peritoneal cavity. All of which removed and the hepatic cyst cleaned. Patient passed a smooth postoperative period and discharged well after 12 days on albendazole tablet. Case 5 A 35 years old man presented to the emergency unit because of sudden central abdominal pain. There was no history of trauma. His examination revealed pulse rate of 110/ minute blood pressure 100/80 mm.Hg. Sonographic examination showed a large cyst in right lobe of the liver with presence of daughter cysts and small amount of free intraperitoneal fluid. Chest x ray was normal. Laparotomy confirmed the rupture of hydatid cyst of the liver, which treated by endocystecteomy and removal of all daughter cysts. Patient received hydrocortisone intraoperativley and a tube drain left. He was discharged well after 6 days. Case 6 A 55 years old woman brought in shock state to the emergency unit; she was complaining of sudden abdominal pain and vomiting. Resuscitation started and abdominal examination revealed a distended, tender abdomen. Sonographic examination done which showed presence of large amount of free intraperitoneal fluid and chest x ray was normal .Explorative laparotomy performed, abdomen was filled with hundreds of small hydatid cysts, with ruptured cysts found in liver and in mesentery of small bowel. Patient received hydrocortisone pre and postoperatively and despite the resuscitating measures patient's condition continues to deteriorate and finally patient died shortly after operation. Case 7 A 13 years old boy was admitted to the emergency surgical unit because of a generalized abdominal pain, that occurred after falling on the ground while playing with his friends one day before admission. The pain was dull in nature and after few hours it was localized in right iliac fossa and became more severe the patient got also nausea, anorexia with low grade fever. The abdomen was soft, with tenderness in right iliac fossa &positive rebound tenderness. There was leucocytosis and his urine exam was normal. Ultrasound examination was not available. Provisional diagnosis of acute appendicitis was reached, and because of history of trauma, the abdomen opened through lower mid line incision. Appendix found normal, and there was a large amount of intraperitoneal fluid, so the incision extended upward and a ruptured cyst of the spleen found which was involving most of the spleen so spleenectomy was performed. Abdomen closed with drain. Patient discharged well after 10 days on albendazole and monthly benzathine penicillin. His Chest x ray postoperatively was normal. Results Over The period of the study (about 3 Unusual presentation of a common disease Mazin Abdullah, Noori Jasim, Furat Shani Bas J Surg, September, 12, 2006 years) 69 patients had undergone surgery for hydatid cyst in the abdomen in Basra General Hospital, 7 of who presented as acute rupture of the hydatid cyst in the peritoneum that is to say 10.14% of the cases. Rupture of the cyst was secondary to trauma in 2 patients and occurred spontaneously in 5 patients. Diagnosis was made preoperatively in 3 patients by the aid of ultrasanographic examination. Anaphylactic shock was present in 4 patients. Five patients had the cyst in the liver, one patient had the cyst in the liver & mesentery & one patient had the cyst in the spleen. No lung hydatid found in these patients. Summary of the cases seen in the table I.