Cytokines (IL-1 ?, IL-6, IL-18, TNF-?) in Blood and Cerebrospinal Fluid in Neonatal Hypoxia/Ischemia)

The most common consequence of this devastating pathophysiologic event is neonatal encephalopathy (NE), or what is commonly recognized in clinical practice as hypoxic-ischemic encephalopathy (HIE). It is estimated that about 30% of children with NE in well developed countries and 60% of children with NE in less developed countries have some evidence of intrapartum hypoxiaischemia. A still high percentage (20-50%) of asphyxiated children with HIE die in the newborn period, with the other quarter developing more severe neurological impairment [3].