Modeling of Blood Lead Levels in Astronauts Exposed to Lead From Microgravity-Accelerated Bone Loss | Zendy

Hector D. García | Zendy; Sean M. Hays | Zendy; Joyce S. Tsuji | Zendy

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Modeling of Blood Lead Levels in Astronauts Exposed to Lead From Microgravity-Accelerated Bone Loss

Author(s) -

Hector D. García,

Sean M. Hays,

Joyce S. Tsuji

Publication year - 2013

Publication title -

aviation space and environmental medicine

Language(s) - English

Resource type - Journals

eISSN - 1943-4448

pISSN - 0095-6562

DOI - 10.3357/asem.3698.2013

Subject(s) - lead (geology) , physiologically based pharmacokinetic modelling , environmental science , chemistry , physiology , medicine , pharmacokinetics , biology , paleontology

Most astronauts experiencing prolonged microgravity undergo accelerated bone loss at a whole-body rate of 0.5-1% per month, with some load-bearing bones losing mass at normalized rates up to about 2.6% per month. The accompanying release of lead (Pb) stored in bones would increase the concentration of Pb in the blood (PbB), thereby complicating efforts to set acceptable Pb concentrations for spacecraft drinking water (PbW).

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