Do Stereoisomers of Homocysteic Acid Exhibit Different Convulsant Action in Immature Rats? | Zendy

Pavel Mareš | Zendy; Jaroslava Folbergrová | Zendy; Renata Haugvicová | Zendy; Hana Kubová | Zendy

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Do Stereoisomers of Homocysteic Acid Exhibit Different Convulsant Action in Immature Rats?

Author(s) -

Pavel Mareš,

Jaroslava Folbergrová,

Renata Haugvicová,

Hana Kubová

Publication year - 2019

Publication title -

physiological research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.647

H-Index - 70

eISSN - 1802-9973

pISSN - 0862-8408

DOI - 10.33549/physiolres.934347

Subject(s) - ampa receptor , convulsant , nmda receptor , chemistry , glutamate receptor , receptor , pharmacology , kainate receptor , neuroscience , biochemistry , medicine , biology

Mechanism of ictogenesis of D- and L-stereroisomers of homocysteic acid was studied in 12-day-old rats by means of antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. There was no qualitative difference between the two stereoisomers in generation of emprosthotonic (flexion) as well as generalized tonic-clonic seizures. Moderate differences were observed in the first, nonconvulsive effects of the two isomers. As generation of the two types of seizures is concerned, NMDA and AMPA participate in generalized tonic-clonic seizures whereas NMDA receptors play a dominant role in generation of flexion seizures.

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