Decreased CD5+ B cells during the acute phase of Kawasaki disease | Zendy

Hee Soo Kim | Zendy; Geun Woong Noh | Zendy; Dong Soo Kim | Zendy; KyungYul Lee | Zendy; Hee Sun Lee | Zendy; Hong Kyu Lee | Zendy; Soon Il Lee | Zendy

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Decreased CD5+ B cells during the acute phase of Kawasaki disease

Author(s) -

Hee Soo Kim,

Geun Woong Noh,

Dong Soo Kim,

KyungYul Lee,

Hee Sun Lee,

Hong Kyu Lee,

Soon Il Lee

Publication year - 1996

Publication title -

yonsei medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.702

H-Index - 63

eISSN - 1976-2437

pISSN - 0513-5796

DOI - 10.3349/ymj.1996.37.1.52

Subject(s) - cd5 , kawasaki disease , medicine , antibody , b cell , immunology , endocrinology , artery

We investigated the changes of CD5+ B cells in the peripheral blood of 20 Kawasaki disease (KD) patients. The percentage of CD5+ B cells in the total lymphocytes and in the total B cells significantly decreased during the acute phase of KD(p < 0.01), compared to that in the age-matched normal control subjects. After intravenous immunoglobulin(IVIG) treatment, the percentage of CD5+ B cells increased, but was still lower than that in the normal controls(p < 0.01). During the convalescent phase of the disease, the percentage of CD5+ B cells was restored to the normal levels. The levels of CD5+ B cell percentage in the total B cells of the patients with acute febrile disease showed similar levels to age-matched normal controls. The decreased CD5+ B cells in the patients with KD provides an additional abnormal immunological finding during the acute phase of the disease.

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