Open AccessAcute Necrotizing Encephalopathy: Diffusion MR Imaging and Localized Proton MR Spectroscopic Findings in Two Infants
Author(s) -
Hyun Woo Goo,
Choong-Gon Choi,
Chong Hyun Yoon,
TaeSung Ko
Publication year - 2003
Publication title -
korean journal of radiology/korean journal of radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.08
H-Index - 57
eISSN - 2005-8330
pISSN - 1229-6929
DOI - 10.3348/kjr.2003.4.1.61
Subject(s) - medicine , in vivo magnetic resonance spectroscopy , diffusion mri , encephalopathy , glutamine , effective diffusion coefficient , neonatal encephalopathy , diffusion imaging , magnetic resonance imaging , diffusion , nuclear magnetic resonance , proton magnetic resonance , radiology , proton , nuclear medicine , pathology , biochemistry , chemistry , physics , amino acid , quantum mechanics , thermodynamics
In this report, we describe the findings of diffusion MR imaging and proton MR spectroscopy in two infants with acute necrotizing encephalopathy in which there was characteristic symmetrical involvement of the thalami. Diffusion MR images of the lesions showed that the observed apparent diffusion coefficient (ADC) decrease was more prominent in the first patient, who had more severe brain damage and a poorer clinical outcome, than in the second. Proton MR spectroscopy detected an increase in the glutamate/glutamine complex and mobile lipids in the first case but only a small increase of lactate in the second. Diffusion MR imaging and proton MR spectroscopy may provide useful information not only for diagnosis but also for estimating the severity and clinical outcome of acute necrotizing encephalopathy.