Metabolism of C(14)-glucose by Eurytrema pancreaticum

1. The glucose uptake rate by Eurytrema pancreaticum was a mean value of 16.44 +/- 2.42 micro moles/hr/g, and total CO2 production rate by the fluke averaged 5.82 +/- 0.97 micro moles/hr/g. The relative specific activity of respiratory CO2 showed a mean value of 5.75 +/- 0.84 per cent. The rate of CO2 production derived from medium C(14)-glucose was a mean of 0.33 +/- 0.10 micor-mole/hr/g. Therefore, the average value of 0.32 +/- 0.04 per cent of glucose utilized by the flukes from the medium C(14)-glucose was oxidized to respiratory CO2. 2. The tissue concentration of glycogen in E. pancreaticum was a mean of 45.50 +/- 2.18 mg/g or 4.55 +/- 0.22 %/g. But the turnover rate of glycogen pool was a mean of 0.027 +/- 0.003 %/hr or 0.009 +/- 0.002 mg/hr/g. The average value of 0.64 +/- 0.23 percent of glucose utilized by the flukes from the medium C(14)-glucose was incorporated into the glycogen. 3. These data account for that only 1 per cent of the utilized glucose by the flukes participated in furnishing the oxidation into respiratory CO2 and the synthetic process into glycogen.